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The creation of Byhalia Family Health Center in 1979 resulted from the efforts of a group of dedicated local citizens who recognized the urgent need for obtaining health care for the medically underserved population of Marshall, Tate and Desoto Counties.  The local group incorporated Northeast Mississippi Health Care, Inc. (NEMHC, Inc.) in 1979 as a nonprofit private corporation and received a grant from the United States Public Health Services to equip and open a Community Health Center in Byhalia.

In April 1993, Mt. Pleasant Family Health Clinic opened to provide easier access to health care for the residents of northern Marshall County.

In July 2014, DeSoto Community Health Center was opened in Southaven, MS with funding provided by Baptist Memorial Foundation to serve DeSoto County residents.

All sites are owned and operated by the communities they serve through volunteer governing Board of Directors.